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NSAIDser forbundet med en del bivirkninger som gjør at disse virkestoffene ikke kan anbefales til alle. Blant annet kan stoffene irritere mageslimhinnen eller idra til å fremkalle astmaanfall. NSAIDs er derfor ikke anbefalt til de som for eksempel har hatt magesår eller som har astma. NSAIDs anbefales heller ikke til gravide.Les også: Klar besk
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